Haz-Map: A Relational Database of Occupational Toxicology
Jay A. Brown, MD, MPH

8 Major Tables in Database

9 Categories of Occupational Diseases
Airway Diseases
Pneumoconioses
Hypersensitivity Pneumonitis
Infections

 9 Categories of Occupational Diseases
Acute Poisons
Chronic Poisons
Metals
Skin Diseases
Cancer

Occupational Diseases Are Preventable
By removing the worker from exposure
By making changes in the workplace

The Knowledge Coupling Problem
The explosion of medical knowledge
The limits of human memory
The need for information
Situation specific
At the point of decision

A Flat File Database Is Like an Electronic Filing Cabinet
Gather information;
Sift through information;
Add file folders;
File information;
Revise file folders;
Continue at step 1;

An Intelligent  Relational Database Is Like a Map
A map begins with a broad outline.
Details are added.
Part-to-whole relationships are depicted.
Intended use determines selection of content.

Haz-Map Is a Map to Be Used:
By health and safety professionals
Physicians
Nurses
Industrial Hygienists
To assist in diagnosis and prevention

The Broad Outline of Haz-Map Is Eight Related Tables

Haz-Map Uses Standard Coding Classification Systems

The Chemicals Level

Toxic Chemicals Can Damage One or More Organ Systems
Lung Toxins
Neurotoxins
Skin Toxins
Hematotoxins
Hepatotoxins
Liver/Kidney/Reproductive Toxins
Carcinogens

The Agents Form:  Adverse Effects

The Agents Form: Agent Profile

The Agents Form: Exposure Assessment

The Diseases Level

Identification of Hazardous Job Tasks Is Crucial for Prevention
It is not the mere presence of chemicals in the workplace that puts the workers at risk.
Hazardous job tasks open one or more exposure routes, usually skin absorption or inhalation.
What is the specific job task that puts the workers at risk for the disease?

Examples of the 178 Hazardous Job Tasks
Manufacture polyurethane products
Remove insulation installed before 1975
Extract coal
Inhale dust of moldy hay, silage, straw or grain

Examples of the 178 Hazardous Job Tasks
Handle medical needles or surgical instruments;
Operate internal combustion engine with inadequate ventilation;
Repair or maintain gasoline or jet fuel tanks;
Remove lead coatings;

Finding Information at the Diseases Level: 3 Examples
What are the hazardous job tasks in the shipyard industry, SIC 3731?
What are the findings and hazardous job tasks associated with exposure to lead?
Carpenters are at increased risk for what diseases?

Job Tasks in the Shipyards, SIC 3731

Lead Poisoning: Findings & Job Tasks

Results of Query-by-Example for Diseases Linked to “carpenters”

Why Occupational Diseases Are Difficult to Recognize
Look like non-occupational diseases
Latency between exposure and disease
Inadequate training of medical students
Thousands of jobs, chemicals and diseases

Chemicals Cause Disease If Three Conditions Are Met:
The chemical is toxic—it can damage one or more organs;
An exposure route exists for the chemical to enter the body;
A sufficient dose is received;

The Need for Toxicology Information in the Clinic
To recognize diseases as occupational and prevent other cases in the workplace;
To give accurate risk communication and prevent disease caused by the fear of chemicals;

The Surveillance Cycle
Collection of data
Analysis and interpretation
Dissemination
Action to control and prevent

The e-Surveillance Cycle

In Summary
If recognized, occupational diseases are preventable.
To recognize them, health & safety professionals need quick access to comprehensive information.
A relational database of occupational toxicology can store and display summarized information for clinical and preventive decision support.
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